Acute Inflammatory Response and Its Control by Nonsteroidal Anti-Inflamatory Drug in Dairy Cows during Early Lactation

Abstract

There is growing metabolic stress and signs of acute inflammation in cows in early lactation. The acute inflammatory response and metabolic status of cows are related to each other, so that dominance of homeorhetic process leads to the development of acute inflammatory response, which further emphasizes homeorhetic adaptation. These processes can significantly collapse state of health and the value of a productivity in cows. In this paper we described the possibility of interruption of the feedback using non-steroidal anti-inflammatory drugs in cows in early lactation. We have described effects of flunixin, ketoprofen and acetyl salicylic acid of the inflammatory response and the health of the cows.

Kod krava u ranoj laktaciji postoji izražen metabolički stres i znaci akutne inflamacije. Akutni inflamatorni odgovor i metabolički status krava su u međusobnoj vezi, tako da dominacija homeretskih procesa dovodi do razvoja aktutnog inflamatornog odgovora, koji dalje potencira homeoretsku adaptaciju. Navedeni procesi mogu značajno da uruše zdravstveno stanje i produktivne vrednosti krava. U ovom preglednom radu opisana je mogućnost prekida ove povratne sprege upotrebom nesteroidnih antiinflamatornih lekova kod krava u ranoj laktaciji. Opisani su efekti fluniksina, acetilsalicilne kiseline i ketoprofena na inflamatorni odgovor i zdravlje krava.