Antimicrobialactivity and Phenolic Composition of the Salvia Verticillata L.Plant Extract

Abstract

The aim of this study was to investigatethe total content of phenolic compounds, flavonoids and phenolic acids,examine the antimicrobial activity of the methanolic extract of S. verticillata aerial part, and demonstrate the presence of rosmarinic acid. The extract was rich in total phenolic content, especially in the total flavonoids content. Using the thin layer chromatography method, rosmarinic acid was identified in the extract.The extract showed moderate to weak antibacterial activity with MIC values of 1.25 to 20 mg/mL and significantly lower antifungal activity. The obtained results suggest that S. verticillata could be subjected to further studies of its pharmacological potential.

Cilj ovog rada je bio određivanje ukupne količine fenolnih jedinjenja, flavonoida i fenolnih kiselina, ispitivanje antimikrobne aktivnosti metanolnog ekstrakta nadzemnog dela biljke S. verticillata, kao i dokazivanje prisustva ruzmarinske kiseline. Ekstrakt je sadržao značajnu količinu ukupnih fenolnih jedinjenja, pri čemu se izdvojio po visokom sadržaju flavonoida.TLC hromatografijom pokazano je prisustvo ruzmarinske kiseline u ovom ekstraktu. Ekstrakt je pokazao umerenu do slabu antibakterijsku aktivnost sa MIK vrednostima od 1,25 do 20 mg/mLi znatno slabiju antifungalnu aktivnost. Dobijeni rezultati sugerišu da se mogu nastaviti dalja ispitivanja farmakološkog potncijala biljkeS. verticillata.