Hypoglycemic Effect of Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D)
Hipoglikemijski efekt herbicida 2,4-dihlorfenoksisirćetna kiselina (2,4-D)
Pregled/ Otvaranje
Autor
Mikov, Ivan
Vasovic, Velibor
Mikov, Aleksandra
Golocorbin-Kon, Svetlana
Stankov, Karmen
Mikov, Momir
Ključne reči
2,4-Dichorophenoxyacetic acidHerbicide
Glucose
Liver
Mice
2,4-dihlorfenoksisirćetna kiselina
herbicid
glukoza
jetra
miš
Metadata
Prikaz svih podataka o dokumentuApstrakt
Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), a synthetic auxin which promotes
uncontrolled plant growth is widely used. The aim of our study was to investigate, using an
experimental model, the effect of herbicide 2,4-D on liver function tests, enzyme a amylase
and glucose blood level. BALB/C mice were treated i.p. with the herbicide (30 mg/
kg 2,4-D) for four consecutive days. Twenty-four hours after the last injection, the treated
and the control animals were weighed and sacrificed for biochemical analysis: haematocrit,
glucose blood level, serum activities of enzymes alanine aminotransferase, aspartate
aminotransferase, gamma glutamyl transferase, and a amylase, as well as liver reduced glutathione.
Herbicide 2,4-D significantly decreased glucose blood level in mice. There were
no changes in liver function tests or activity of enzyme a amylase. In this study on mice we
confirmed the results obtained in the previous study, which showed a hypoglycemic effect
of herbicide 2,4-D on agricultural workers. To elucidate the mechanism of this effect, a further
research is needed. Primena herbicida 2,4-dihlorfenoksisirćetne kiseline (2,4-D), sintetskog auksina koji podstiče
nekontrolisani rast biljke, u svetu je veoma rasprostranjena. Cilj ovog rada bio je da
se, korišćenjem eksperimentalnog modela, ispita uticaj herbicida 2,4-D na funkcije jetre, aktivnost
enzima a amilazu i nivo glukoze u krvi. BALB/C miševi tretirani su intraperitonealno
četiri uzastopna dana herbicidom (30 mg/kg 2,4-D). Dvadeset četiri časa nakon završenog
tretmana, tretirane i kontrolne životinje su izmerene i žrtvovane radi određivanja: hematokrita,
nivoa glukoze u krvi, serumske aktivnosti enzima alanin-aminotransferaze, aspartat-
aminotransferaze, gama-glutamil transferaze i a-amilaze, kao i redukovanog glutationa
jetre. Herbicid 2,4-D značajno je smanjio nivo glukoze u krvi kod miševa. Nije nađena razlika
u funkcijama jetre ili aktivnosti enzima a-amilaze. Ovi rezultati su u skladu sa rezultatima
prethodnog istraživanja kod poljoprivrednih radnika o hipoglikemijskom delovanju herbicida
2,4-D. Radi razjašnjavanja mehanizma ovog delovanja neophodna su dalja istraživanja.