Hypoglycemic Effect of Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D)
Hipoglikemijski efekt herbicida 2,4-dihlorfenoksisirćetna kiselina (2,4-D)
dc.contributor.author | Mikov, Ivan | |
dc.contributor.author | Vasovic, Velibor | |
dc.contributor.author | Mikov, Aleksandra | |
dc.contributor.author | Golocorbin-Kon, Svetlana | |
dc.contributor.author | Stankov, Karmen | |
dc.contributor.author | Mikov, Momir | |
dc.date.accessioned | 2015-11-07T14:11:42Z | |
dc.date.available | 2015-11-07T14:11:42Z | |
dc.identifier.uri | http://arhiva.nara.ac.rs/handle/123456789/1378 | |
dc.description.abstract | Herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), a synthetic auxin which promotes uncontrolled plant growth is widely used. The aim of our study was to investigate, using an experimental model, the effect of herbicide 2,4-D on liver function tests, enzyme a amylase and glucose blood level. BALB/C mice were treated i.p. with the herbicide (30 mg/ kg 2,4-D) for four consecutive days. Twenty-four hours after the last injection, the treated and the control animals were weighed and sacrificed for biochemical analysis: haematocrit, glucose blood level, serum activities of enzymes alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transferase, and a amylase, as well as liver reduced glutathione. Herbicide 2,4-D significantly decreased glucose blood level in mice. There were no changes in liver function tests or activity of enzyme a amylase. In this study on mice we confirmed the results obtained in the previous study, which showed a hypoglycemic effect of herbicide 2,4-D on agricultural workers. To elucidate the mechanism of this effect, a further research is needed. | en |
dc.description.abstract | Primena herbicida 2,4-dihlorfenoksisirćetne kiseline (2,4-D), sintetskog auksina koji podstiče nekontrolisani rast biljke, u svetu je veoma rasprostranjena. Cilj ovog rada bio je da se, korišćenjem eksperimentalnog modela, ispita uticaj herbicida 2,4-D na funkcije jetre, aktivnost enzima a amilazu i nivo glukoze u krvi. BALB/C miševi tretirani su intraperitonealno četiri uzastopna dana herbicidom (30 mg/kg 2,4-D). Dvadeset četiri časa nakon završenog tretmana, tretirane i kontrolne životinje su izmerene i žrtvovane radi određivanja: hematokrita, nivoa glukoze u krvi, serumske aktivnosti enzima alanin-aminotransferaze, aspartat- aminotransferaze, gama-glutamil transferaze i a-amilaze, kao i redukovanog glutationa jetre. Herbicid 2,4-D značajno je smanjio nivo glukoze u krvi kod miševa. Nije nađena razlika u funkcijama jetre ili aktivnosti enzima a-amilaze. Ovi rezultati su u skladu sa rezultatima prethodnog istraživanja kod poljoprivrednih radnika o hipoglikemijskom delovanju herbicida 2,4-D. Radi razjašnjavanja mehanizma ovog delovanja neophodna su dalja istraživanja. | sr |
dc.subject | 2,4-Dichorophenoxyacetic acid | en |
dc.subject | Herbicide | sr |
dc.subject | Glucose | en |
dc.subject | Liver | en |
dc.subject | Mice | sr |
dc.subject | 2,4-dihlorfenoksisirćetna kiselina | sr |
dc.subject | herbicid | sr |
dc.subject | glukoza | sr |
dc.subject | jetra | sr |
dc.subject | miš | sr |
dc.title | Hypoglycemic Effect of Herbicide 2,4-Dichlorophenoxyacetic Acid (2,4-D) | en |
dc.title.alternative | Hipoglikemijski efekt herbicida 2,4-dihlorfenoksisirćetna kiselina (2,4-D) | sr |
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VOL 25 *No.4
http://www.pesting.org.rs/2010.php