| dc.description.abstract | Here we determined antioxidant, antimicrobial and anticancer properties of edible mushroom Agaricus campestris. Antioxidant activity was evaluated by free radical scavenging, superoxide anion scavenging and reducing power. A. campestris extract had moderate free radical scavenging activity (IC50=179.65 µg/mL) and potent superoxide anion scavenging potential (IC50=35.204 µg/mL). Measured values of absorbance for reducing power varied from 0.3701 to 0.141. Further, the antimicrobial potential was determined by a microdilution method on 12 microorganisms. Extract of A. campestris showed relatively strong antimicrobial activity with minimum inhibitory concentration values ranging from 0.08 to 7.5 mg/mL. Finally, the cytotoxic activity was tested using MTT method on the human epithelial carcinoma Hela cells, human lung carcinoma A549 cells and human colon carcinoma LS174 cells. A. campestris extract expressed cytotoxic activity with IC50 values ranging from 9.54 to 16.87 μg/mL. | sr |
